activator protein 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5416	T-5224		MMP
	T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.		MMP
T23384	SR 11302		DNA/RNA Synthesis
	SR 11302 is an inhibitor of activator protein-1 (AP-1).		DNA/RNA Synthesis
T9010	IMM-H007		Others , AMPK
	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression		Others , AMPK
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T9347	EAAT2 activator 1	3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine	transporter
	EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) is a thiopyridazine derivative that has been found to increase EAAT2 protein levels in astrocytes.		transporter
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T6007	Birinapant	TL32711	Apoptosis , IAP , HIV Protease
	Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with po...		Apoptosis , IAP , HIV Protease
T24816	SP-100030	SP100030,SP 100030	NF-κB
	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ...		NF-κB
T4868	Gamma-Linolenic acid	gamolenic acid,γ-Linolenic acid	Endogenous Metabolite
	gamma-Linolenic acid (gamolenic acid), is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown γ-Linolenic Acid to have induced r...		Endogenous Metabolite
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase
T2310L	CHIR-99021 HCl	CT99021 HCl,Laduviglusib HCl	GSK-3
	CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit...		GSK-3
T70620	VU0466551
	VU0466551 is a selective activator of homomeric G protein gated, inwardly rectifying, potassium subunit 1 (GIRK1) channels.
T28818	SMAPP1
	SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.
T25251	CID-7309015
	CID-7309015 is a human tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor, delayed death of the malarial parasite plasmid, the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with pe...
TP1689	TAT (48-57) TFA(253141-50-3,free)	TAT (48-57) TFA
	TAT (48-57) (TFA) is a cellular permeability peptide derived from hiv-1 transcriptional activator (TAT) protein residue 48-57.
T74466	ASR-488
	ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].
T73224	AMPK-IN-1
	AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. It induces phosphorylation of eEF2 independent of the mTORC1 pathway.
T82952	ATF3 inducer 1
	ATF3 Inducer 1 is a potent activator of ATF3, enhancing both ATF3 protein and mRNA levels, and exhibits anti-metabolic syndrome (anti-MetS) activity in mice [1].
TN5593	Euphohelioscopin A
	Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it ex...
T61081	DFPM
	DFPM, a chemical compound, acts as an activator of the plant resistance protein signaling in roots, thereby causing inhibition of root growth. It also reduces the viability of root cells specifically in the Col-0 accessi...